Trude Rein was born in Essen (West Germany) in 1908. She studied at the school of Applied Arts in Hanover, and probably trained as illustrator. In 1935 she moved to Berlin to continue her studies. From 1939 she worked as a teacher in the Textile-und-Modenschule in Berlin, while also working as freelance fashion illustrator.
After the war, she was appointed professor of fashion illustration in several academies in Berlin, and helped generations of students to form their visual language in fashion.
Her collaborations counted fashion magazines, but also companies manufacturers and newspaper.